Institutionen för medicinska vetenskaper

Publikationer

Selekterade originalpublikationer

1: Imgenberg-Kreuz J, Sandling JK, Almlöf JC, Nordlund J, Signér L, Norheim KB, Omdal R, Rönnblom L, Eloranta ML, Syvänen AC, Nordmark G. Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren's syndrome reveals regulatory effects at interferon-induced genes. Ann Rheum Dis. 2016 Nov;75(11):2029-2036. doi: 10.1136/annrheumdis-2015-208659. PubMed PMID: 26857698; PubMed Central PMCID: PMC5099203.

2: Berggren O, Rönnblom L, Eloranta ML. Effect of PTPN22 Gene Variant R620W on Type I Interferon Production Stimulated by Different Toll-like Receptor 7 Agonists: Comment on the Article by Wang et al. Arthritis Rheumatol. 2016 Apr;68(4):1045. doi: 10.1002/art.39571. PubMed PMID: 26748951.

3: Leonard D, Eloranta ML, Hagberg N, Berggren O, Tandre K, Alm G, Rönnblom L. Activated T cells enhance interferon-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes. Ann Rheum Dis. 2016 Sep;75(9):1728-34. doi: 10.1136/annrheumdis-2015-208055. PubMed PMID: 26493814.

4: Berggren O, Alexsson A, Morris DL, Tandre K, Weber G, Vyse TJ, Syvänen AC, Rönnblom L, Eloranta ML. IFN-α production by plasmacytoid dendritic cell associations with polymorphisms in gene loci related to autoimmune and inflammatory diseases. Hum Mol Genet. 2015 Jun 15;24(12):3571-81. doi: 10.1093/hmg/ddv095. PubMed PMID: 25779693.

5: Allum F, Shao X, Guénard F, Simon MM, Busche S, Caron M, Lambourne J, Lessard  J, Tandre K, Hedman ÅK, Kwan T, Ge B; Multiple Tissue Human Expression Resource Consortium., Rönnblom L, McCarthy MI, Deloukas P, Richmond T, Burgess D, Spector  TD, Tchernof A, Marceau S, Lathrop M, Vohl MC, Pastinen T, Grundberg E. Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants. Nat Commun. 2015 May 29;6:7211. doi: 10.1038/ncomms8211. Erratum in: Nat Commun. 2015;6:8016. PubMed PMID: 26021296; PubMed Central PMCID: PMC4544751.

6: Hagberg N, Theorell J, Hjorton K, Spee P, Eloranta ML, Bryceson YT, Rönnblom L. Functional anti-CD94/NKG2A and anti-CD94/NKG2C autoantibodies in patients with systemic lupus erythematosus. Arthritis Rheumatol. 2015 Apr;67(4):1000-11. doi: 10.1002/art.38999. PubMed PMID: 25510434.

7: Hagberg N, Theorell J, Schlums H, Eloranta ML, Bryceson YT, Rönnblom L. Systemic lupus erythematosus immune complexes increase the expression of SLAM family members CD319 (CRACC) and CD229 (LY-9) on plasmacytoid dendritic cells and CD319 on CD56(dim) NK cells. J Immunol. 2013 Sep 15;191(6):2989-98. doi: 10.4049/jimmunol.1301022. PubMed PMID: 23956418.

8: Lessard CJ, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, Kelly JA, Dozmorov MG, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun  JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Jazebi H, Cunninghame Graham DS, Grandits ME, Nazmul-Hossain AN, Patel K, Adler AJ, Maier-Moore JS, Farris AD, Brennan MT, Lessard JA, Chodosh J, Gopalakrishnan R, Hefner KS, Houston GD, Huang AJ, Hughes PJ, Lewis DM, Radfar L, Rohrer MD, Stone  DU, Wren JD, Vyse TJ, Gaffney PM, James JA, Omdal R, Wahren-Herlenius M, Illei GG, Witte T, Jonsson R, Rischmueller M, Rönnblom L, Nordmark G, Ng WF; UK Primary Sjögren's Syndrome Registry., Mariette X, Anaya JM, Rhodus NL, Segal BM, Scofield RH, Montgomery CG, Harley JB, Sivils KL. Variants at multiple loci implicated in  both innate and adaptive immune responses are associated with Sjögren's syndrome. Nat Genet. 2013 Nov;45(11):1284-92. doi: 10.1038/ng.2792. PubMed PMID: 24097067;  PubMed Central PMCID: PMC3867192.

9: Adoue V, Schiavi A, Light N, Almlöf JC, Lundmark P, Ge B, Kwan T, Caron M, Rönnblom L, Wang C, Chen SH, Goodall AH, Cambien F, Deloukas P, Ouwehand WH, Syvänen AC, Pastinen T. Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs. Mol Syst Biol. 2014 Oct 16;10:754. doi: 10.15252/msb.20145114. PubMed PMID: 25326100; PubMed Central PMCID: PMC4299376.

10: Liang L, Willis-Owen SA, Laprise C, Wong KC, Davies GA, Hudson TJ, Binia A, Hopkin JM, Yang IV, Grundberg E, Busche S, Hudson M, Rönnblom L, Pastinen TM, Schwartz DA, Lathrop GM, Moffatt MF, Cookson WO. An epigenome-wide association study of total serum immunoglobulin E concentration. Nature. 2015 Apr 30;520(7549):670-4. doi: 10.1038/nature14125. PubMed PMID: 25707804; PubMed Central PMCID: PMC4416961.

11: Brauner S, Zhou W, Backlin C, Green TM, Folkersen L, Ivanchenko M, Löfström B, Xu-Monette ZY, Young KH, Møller Pedersen L, Boe Møller M, Sundström C, Enblad G, Baecklund E, Wahren-Herlenius M. Reduced expression of TRIM21/Ro52 predicts poor prognosis in diffuse large B-cell lymphoma patients with and without rheumatic disease. J Intern Med. 2015 Sep;278(3):323-32.

12: Knight A, Hjorton K, Sundström C, Höglund M, Backlin C, Smedby KE, Askling J, Baecklund E. Leukemia and Myelodysplastic Syndrome in Granulomatosis with Polyangiitis: Subtypes, Clinical Characteristics, and Outcome. J Rheumatol. 2015 Apr;42(4):690-4.

13: Vasaitis L, Sundström C, Backlin C, Nordmark G, Baecklund E. Sporadic occurrence of non-diagnosed IgG4-related disease in lymphoma patients with a previous Sjögren's syndrome diagnosis. Acta Oncol 2016;55:1139-1144.

14: Hellgren K, Baecklund E, Backlin C, Sundstrom C, Smedby KE, Askling J. Rheumatoid Arthritis and Risk of Malignant Lymphoma - Is the risk still increased? Arthritis Rheumatol 2016 Dec 19. [Epub ahead of print]

Selekterade översiktsartiklar

1: Rönnblom L. The importance of the type I interferon system in autoimmunity. Clin Exp Rheumatol. 2016 Jul-Aug;34(4 Suppl 98):21-4. Review. PubMed PMID: 27586799.

2: Bengtsson AA, Rönnblom L. Systemic lupus erythematosus: still a challenge for  physicians. J Intern Med. 2017 Jan;281(1):52-64. doi: 10.1111/joim.12529. Review. PubMed PMID: 27307107.

3: Eloranta ML, Rönnblom L. Cause and consequences of the activated type I interferon system in SLE. J Mol Med (Berl). 2016 Oct;94(10):1103-1110. Review. PubMed PMID: 27094810; PubMed Central PMCID: PMC5052287.

4: Eloranta ML, Alm GV, Rönnblom L. Disease mechanisms in rheumatology--tools and pathways: plasmacytoid dendritic cells and their role in autoimmune rheumatic diseases. Arthritis Rheum. 2013 Apr;65(4):853-63. doi: 10.1002/art.37821. Review. PubMed PMID: 23280551.

5: Rönnblom L, Eloranta ML. The interferon signature in autoimmune diseases. Curr Opin Rheumatol. 2013 Mar;25(2):248-53. doi: 10.1097/BOR.0b013e32835c7e32. Review. PubMed PMID: 23249830.

6: Nordmark G, Eloranta ML, Ronnblom L. Primary Sjögren's syndrome and the type I interferon system. Curr Pharm Biotechnol. 2012 Aug;13(10):2054-62. Review. PubMed PMID: 22208657.

7: Baecklund E, Smedby KE, Sutton LA, Askling J, Rosenquist R. Lymphoma development in patients with autoimmune and inflammatory disorders - What are the driving forces?  Semin Cancer Biol. 2014 Feb;24:61-70.