Department of Medical Sciences

Young Investigator award to Daniel Espes

2018-04-19

The Scandinavian Society for the Study of Diabetes (SSSD) awards

Daniel espes

once annually a younginvestigator who has published an important research article within the field of experimental or clinical diabetes research. This year, Daniel Espes from Uppsala University was selected for the Young Investigator Award at the meeting in Turku in April 2018.

 The award consists of a diploma a cash prize of 10 000 Norwegian Krones. In 2017 Daniel Espes published an article in Diabetes Care describing that approximately 40 % of patients with long-standing type 1 diabetes have residual endogenous insulin production. Remaining endogenous insulin production did not affect markers of metabolic control or exogenous insulin requirements. However, patients with residual insulin production have higher levels of the anti-inflammatory cytokine IL-35. In addition, these patients displayed a more favorable immunological profile. This is of importance for our view on the pathophysiology of type 1 diabetes as well as for identifying novel therapies aiming to restore beta-cell mass.

-Based on these findings we are now conducting a clinical intervention trial in patients with long-standing type 1 diabetes and residual insulin production with the aim to expand residual beta-cell mass.

Reference:

Increased Interleukin-35 Levels in Patients With Type 1 Diabetes With Remaining C-Peptide. Espes D, Singh K, Sandler S and Carlsson PO. Diabetes Care, 2017 Aug;40(8):1090-1095. doi: 10.2337/dc16-2121.