The PIVUS study started in 2001 with the primary aim to investigate the predicive power of different measurements of endothelial function and arterial compliance in a random sample of 1000 subjects aged 70 living in the community of Uppsala. As secondary aims, the study also included measurements of cardiac function and structure by ultrasound and MRI, evaluation of atherosclerosis by ultrasound and MRI, 7 day food intake recordings, detailed ECG analysis, cardiovascular autonomic function, body composition by DXA, DNA analysis and lung function, as well as a number of biochemical markers.
The inclusion of subjects in the study was completed in June 2004 by the team below:
Anna Stenborg, Kerstin Marttala, Lars Lind, Jan Hall
In March 2006 a reinvesigation of the cohort at the age of 75 was started. The major measurements performed at age 70 will be repeated at age 75. In addition, we will focus on infarcts in the brain and heart, so both of these items will be investigated by brain and myocardial MRI in all subjects. Also cognitive tests are included in the reinvestigation that was completed in September 2009.Of the initial 1016 subjects, 52 had died during the 5 years and 827 attended the re-examination at age 75.
In the spring of 2011 we started the 80-year reinvestigation of the cohort. This round will continue until the summer of 2014 and we expect that 500-600 of the original sample will attend. We measure the traditional CV risk factors, 2 cognitive function tests, ultrasound of the carotid arteries and the heart, a DXA scan and an MRI scan of the brain and abdominal region.