Publikationer
Håkan Melhus artiklar i PubMed
Mia Wadelius artiklar i PubMed
Maria Gabriella Scordos artiklar i PubMed
Utvalda publikationer
1.International Warfarin Pharmacogenetics Consortium, Klein TE, Altman RB, et al Warfarin dosing using clinical and pharmacogenetic data. N Engl J Med 2009 Feb 19;360:753-64.
2.Byberg L, Melhus H, Gedeborg R, Sundström J, Ahlbom A, Zethelius B, Berglund LG, Wolk A, Michaëlsson K. Total mortality after changes in leisure time physical activity in 50 year old men: 35 year follow-up of population based cohort. BMJ 2009; 338:b688.
3.Michaëlsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med 2003; 348:287-94.
4.Hallberg P, Michaëlsson K, Melhus H. Digoxin for the treatment of heart failure. N Engl J Med 2003; 348:661-62.
5.Carling T, Kindmark A, Hellman P, Lundgren E, Ljunghall S, Rastad J, Åkerström G, and Melhus H. Vitamin D receptor genotypes in hyperparathyroidism. Nature Medicine 1995;1:1309-11.
6.Melhus H, Kindmark A, Amér S, Wilén B, Lindh E, Ljunghall S. Vitamin D receptor genotypes in osteoporosis. Lancet 1994; 344: 949-950.
7.Glimelius B, Garmo H, Berglund Å, Fredriksson LA, Berglund M, Byström P, Kohnke H, Sørbye H, Wadelius M. Prediction of irinotecan and 5-FU toxicity and response in patients with advanced colorectal cancer. Pharmacogenomics J 2011, Feb;11(1):61-71.
8.Limdi NA, Wadelius M, Cavallari L. Eriksson N, Crawford D, Lee MTM, Chen CH, Motsinger-Rief A, Sagreiya H, Liu N, Wu AHB, Gage BF, Jorgensen A, Pirmohamed M, Shin JG, Suarez-Kurtz G, Kimmel SE, Johnson JA, Klein TE, Wagner MJ on behalf of the IWPC. Warfarin Pharmacogenetics:VKORC1 genotype as predictive as haplotype across three racial groups. Blood 2010 May 6;115(18):3827-34.
9.Takeuchi F, McGinnis R, Bourgeois S, Barnes C, Eriksson N, Soranzo N, Whittaker P, Ranganath V, Kumanduri V, McLaren W, Holm L, Lindh JD, Rane A, Wadelius M, Deloukas P. A genome-wide association study confirms VKORC1, CYP2C9 and CYP4F2 as principal genetic determinants of warfarin dose. PLoS Genetics 2009 March 20;5:e1000433.
10.Sundström A, Hallberg P. Data-mining in pharmacovigilance - detecting the unexpected: the role of index of suspicion of the reporter. Drug Safety 2009;32(5):419-27.
Publikationer från Klinisk farmakogenomik och osteoporos
Här visas de 50 senaste publikationerna från forskargruppen Klinisk farmakogenomik och osteoporos.
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Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events
Ingår i Frontiers in Genetics, 2022.
Artikel i tidskrift
DOI för Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events Ladda ner fulltext (pdf) av Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events
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Risk of Revision After Arthroplasty Associated withSpecific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 TwinsTreated with Arthroplasty
Ingår i Journal of Bone and Joint Surgery, s. 610-620, 2022.
Artikel i tidskrift
DOI för Risk of Revision After Arthroplasty Associated withSpecific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 TwinsTreated with Arthroplasty Ladda ner fulltext (pdf) av Risk of Revision After Arthroplasty Associated withSpecific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 TwinsTreated with Arthroplasty
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Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate
Ingår i Pharmacogenomics (London), s. 813-820, 2022.
Artikel i tidskrift
DOI för Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate Ladda ner fulltext (pdf) av Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate
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The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms
Ingår i Clinical Pharmacology and Therapeutics, s. 1007-1021, 2022.
Artikel i tidskrift
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Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
Ingår i Cell Reports Medicine, s. 100763-100763, 2022.
Artikel i tidskrift
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Implementing precision medicine in a regionally organized healthcare system in Sweden.
Ingår i Nature Medicine, s. 1980-1982, 2022.
Artikel i tidskrift
DOI för Implementing precision medicine in a regionally organized healthcare system in Sweden.
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Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial
Ingår i British Journal of Clinical Pharmacology, 2022.
Artikel i tidskrift
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Mast cell chymase has a negative impact on human osteoblasts
Ingår i Matrix Biology, s. 1-19, 2022.
Artikel i tidskrift
DOI för Mast cell chymase has a negative impact on human osteoblasts Ladda ner fulltext (pdf) av Mast cell chymase has a negative impact on human osteoblasts
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Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes.
Ingår i Frontiers in Genetics, s. 914376-, 2022.
Artikel i tidskrift
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Chapter 73: Pharmacogenetics
Ingår i Tietz Textbook of Laboratory Medicine, 7th Edition, 2022.
Kapitel i bok, del av antologi
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The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design
Ingår i BMC Medicine, 2022.
Artikel i tidskrift
DOI för The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design Ladda ner fulltext (pdf) av The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design
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Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden
Ingår i Respiratory Medicine, 2022.
Artikel i tidskrift
DOI för Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden Ladda ner fulltext (pdf) av Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden
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HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease
Ingår i Clinical and Translational Science, s. 1249-1256, 2022.
Artikel i tidskrift
DOI för HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease Ladda ner fulltext (pdf) av HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease
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Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes
Ingår i Bone Reports, 2021.
Artikel i tidskrift
DOI för Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes
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[Pharmacogenomics - a cornerstone of Precision Medicine. Genomic Medicine Sweden analyses genotypes associated with serious drug toxicity or therapeutic failure].
Ingår i Läkartidningen, 2021.
Artikel, forskningsöversikt
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Technological readiness and implementation of genomic-driven precision medicine for complex diseases
Ingår i Journal of Internal Medicine, s. 602-620, 2021.
Artikel, forskningsöversikt
DOI för Technological readiness and implementation of genomic-driven precision medicine for complex diseases Ladda ner fulltext (pdf) av Technological readiness and implementation of genomic-driven precision medicine for complex diseases
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Association of Variants Near the Bradykinin Receptor B2 Gene With Angioedema in Patients Taking ACE Inhibitors
Ingår i Journal of the American College of Cardiology, s. 696-709, 2021.
Artikel i tidskrift
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Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate
Ingår i Pharmacogenomics (London), s. 973-982, 2021.
Artikel i tidskrift
DOI för Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate Ladda ner fulltext (pdf) av Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate
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Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial
Ingår i JAMA Network Open, 2021.
Artikel i tidskrift
DOI för Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial Ladda ner fulltext (pdf) av Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial
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Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis
Ingår i Journal of the American Heart Association, 2021.
Artikel i tidskrift
DOI för Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis Ladda ner fulltext (pdf) av Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis
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Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years
Ingår i Journal of Clinical Endocrinology and Metabolism, s. 2840-2854, 2021.
Artikel i tidskrift
DOI för Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years Ladda ner fulltext (pdf) av Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years
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Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index?
Ingår i International Journal of Epidemiology, s. 234-244, 2021.
Artikel i tidskrift
DOI för Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index? Ladda ner fulltext (pdf) av Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index?
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Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study
Ingår i Diabetologia, s. 1348-1357, 2021.
Artikel i tidskrift
DOI för Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study Ladda ner fulltext (pdf) av Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study
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Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens.
Ingår i Clinical Pharmacology and Therapeutics, s. 1125-1135, 2021.
Artikel i tidskrift
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Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema
Ingår i Pharmacogenomics (London), s. 319-321, 2021.
Artikel i tidskrift
DOI för Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema
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Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study
Ingår i European Heart Journal, s. 243-252, 2021.
Artikel i tidskrift
DOI för Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study Ladda ner fulltext (pdf) av Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study
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Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations
Ingår i npj Primary Care Respiratory Medicine, 2021.
Artikel i tidskrift
DOI för Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations Ladda ner fulltext (pdf) av Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations
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High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis
Ingår i Frontiers in Genetics, 2020.
Artikel i tidskrift
DOI för High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis Ladda ner fulltext (pdf) av High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis
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Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations
Ingår i Genes, 2020.
Artikel i tidskrift
DOI för Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations Ladda ner fulltext (pdf) av Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations
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SWEDEGENE: a Swedish nation-wide DNA sample collection for pharmacogenomic studies of serious adverse drug reactions
Ingår i The Pharmacogenomics Journal, s. 579-585, 2020.
Artikel i tidskrift
DOI för SWEDEGENE: a Swedish nation-wide DNA sample collection for pharmacogenomic studies of serious adverse drug reactions Ladda ner fulltext (pdf) av SWEDEGENE: a Swedish nation-wide DNA sample collection for pharmacogenomic studies of serious adverse drug reactions
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MTHFR, TYMS and SLCO1B1 polymorphisms and adverse liver effects of methotrexate in rheumatoid arthritis
Ingår i Pharmacogenomics (London), s. 337-346, 2020.
Artikel i tidskrift
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Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.
Ingår i Journal of Clinical Pharmacy and Therapeutics, s. 1021-1029, 2020.
Artikel i tidskrift
DOI för Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial. Ladda ner fulltext (pdf) av Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.
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Comprehensive medication reviews by ward-based pharmacists in Swedish hospitals: What does the patient have to say?
Ingår i Journal of Evaluation In Clinical Practice, s. 149-157, 2020.
Artikel i tidskrift
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Facilitators and barriers for performing comprehensive medication reviews and follow-up by multiprofessional teams in older hospitalised patients
Ingår i European Journal of Clinical Pharmacology, s. 775-784, 2020.
Artikel i tidskrift
DOI för Facilitators and barriers for performing comprehensive medication reviews and follow-up by multiprofessional teams in older hospitalised patients Ladda ner fulltext (pdf) av Facilitators and barriers for performing comprehensive medication reviews and follow-up by multiprofessional teams in older hospitalised patients
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Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and angiotensin receptor blocker-induced angioedema
Ingår i Clinical Pharmacology and Therapeutics, s. 1195-1202, 2020.
Artikel i tidskrift
DOI för Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and angiotensin receptor blocker-induced angioedema Ladda ner fulltext (pdf) av Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and angiotensin receptor blocker-induced angioedema
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Combined associations of body mass index and adherence to a Mediterranean-like diet with all-cause and cardiovascular mortality: A cohort study
Ingår i PLoS Medicine, 2020.
Artikel i tidskrift
DOI för Combined associations of body mass index and adherence to a Mediterranean-like diet with all-cause and cardiovascular mortality: A cohort study Ladda ner fulltext (pdf) av Combined associations of body mass index and adherence to a Mediterranean-like diet with all-cause and cardiovascular mortality: A cohort study
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Next-Generation Sequencing of CYP2C19 in Stent Thrombosis: Implications for Clopidogrel Pharmacogenomics.
Ingår i Cardiovascular Drugs and Therapy, s. 549-559, 2020.
Artikel i tidskrift
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Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment.
Ingår i The Pharmacogenomics Journal, s. 770-783, 2020.
Artikel i tidskrift
DOI för Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment. Ladda ner fulltext (pdf) av Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment.
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Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders
Ingår i Psychoneuroendocrinology, 2020.
Artikel i tidskrift
DOI för Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders Ladda ner fulltext (pdf) av Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders
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CYP2C9, VKORC1, and CYP4F2 polymorphisms and pediatric warfarin maintenance dose: a systematic review and meta-analysis
Ingår i The Pharmacogenomics Journal, s. 306-319, 2020.
Artikel, forskningsöversikt
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A sensitive method detecting trace levels of levonorgestrel using LC-HRMS.
Ingår i Contraception, s. 247-249, 2019.
Artikel i tidskrift
DOI för A sensitive method detecting trace levels of levonorgestrel using LC-HRMS.
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A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury
Ingår i Gastroenterology, s. 1707-1716, 2019.
Artikel i tidskrift
DOI för A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury
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Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing
Ingår i PLOS ONE, 2019.
Artikel i tidskrift
DOI för Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing Ladda ner fulltext (pdf) av Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing
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Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival
Ingår i EBioMedicine, s. 595-604, 2019.
Artikel i tidskrift
DOI för Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival Ladda ner fulltext (pdf) av Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival
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Disentangling the genetics of lean mass
Ingår i American Journal of Clinical Nutrition, s. 276-287, 2019.
Artikel i tidskrift
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Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice
Ingår i INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, s. 1226-1232, 2019.
Artikel i tidskrift
DOI för Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice Ladda ner fulltext (pdf) av Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice
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A case study of the implementation and sustainability of medication reviews in older patients by clinical pharmacists
Ingår i Research in Social and Administrative Pharmacy, s. 1309-1316, 2019.
Artikel i tidskrift
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Assessment tool for hospital admissions related to medications: development and validation in older patients
Ingår i International Journal of Clinical Pharmacy, s. 198-206, 2019.
Artikel i tidskrift
DOI för Assessment tool for hospital admissions related to medications: development and validation in older patients Ladda ner fulltext (pdf) av Assessment tool for hospital admissions related to medications: development and validation in older patients
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Comprehensive medication reviews in Swedish hospitals: what does the patient have to say?
Ingår i International Journal of Clinical Pharmacy, s. 346-346, 2019.
Artikel i tidskrift