Publications
Håkan Melhus' publications in PubMed
Mia Wadelius' publications in PubMed
Maria Gabriella Scordo's publications in PubMed
Selected publications
Hallberg P, Eriksson N, Ibañez L, Bondon-Guitton E, Kreutz R, Carvajal A, Lucena M, Sancho Ponce E, Sainz Gill M, Douros A, Lapeyre-Mestre M, Montastruc JL, Ruiz-Nuñes J, Stephens CM, Martin J, Axelsson T, Yue QY, Magnusson PK, Wadelius M, on behalf of EuDAC. Genetic variants associated with antithyroid drug-induced agranulocytosis: a genome-wide association study in a European population. Lancet Diabetes Endocrinol 2016;4:507-16.
Pirmohamed M, Burnside G, Eriksson N, Jorgensen AL, Toh CH, Nicholson T, Kesteven P, Christersson C, Wahlström B, Stafberg C, Zhang JE, Leathart JB, Kohnke H, Maitland-van der Zee AH, Williamson PR, Daly AK, Avery P, Kamali F, Wadelius M; the EU-PACT Group. A Randomized Trial of Genotype-Guided Dosing of Warfarin. N Engl J Med 2013;369:2294-2303.
International Warfarin Pharmacogenetics Consortium, Klein TE, Altman RB, Eriksson N, Gage BF, Kimmel SE, Lee MT, Limdi NA, Page D, Roden DM, Wagner MJ, Caldwell MD, Johnson JA, (Chen YT, Wen MS, Caraco Y, Achache I, Blotnick S, Muszkat M, Shin JG, Kim HS, Suarez-Kurtz G, Perini JA, Silva-Assunção E, Anderson JL, Horne BD, Carlquist JF, Berg RL, Burmester JK, Goh BC, Lee SC, Kamali F, Sconce E, Daly AK, Wu AH, Langaee TY, Feng H, Cavallari L, Momary K, Pirmohamed M, Jorgensen A, Toh CH, Williamson P, McLeod H, Evans JP, Weck KE, Brensinger C, Nakamura Y, Mushiroda T, Veenstra D, Meckley L, Rieder MJ, Rettie AE, Wadelius M, Melhus H, Stein CM, Schwartz U, Kurnik D, Lenzini P, Eby C, Chen LY, Deloukas P, Motsinger-Reif A, Sagreiya H, Lantz E, Chang T, Ritchie M, Deych E, Lu LS, Srinivasan BS).Estimation of warfarin dose using clinical and pharmacogenetic data. N Engl J Med 2009;360:753-64.
Michaëlsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med 2003;348:287-94.
Scordo MG, Pengo V, Spina E, Dahl ML, Gusella M, Padrini R. Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance. Clin Pharmacol Ther 2002;72:702-710.
Melhus H, Michaëlsson K, Kindmark A, Bergström R, Holmberg L, Wolk A, Mallmin H, and Ljunghall S. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Ann Intern Med 1998;129: 770-778.
Publications from Clinical pharmacogenetics and osteoporosis
These are the 50 most recent publications from the research group Clinical pharmacogenetics and osteoporosis.
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Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial
Part of British Journal of Clinical Pharmacology, p. 1575-1587, 2023.
Article in journal
DOI for Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial Download full text (pdf) of Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial
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Vitamin D and bone metabolism in Graves’ disease: a prospective study
Part of Journal of Endocrinological Investigation, p. 425-433, 2023.
Article in journal
DOI for Vitamin D and bone metabolism in Graves’ disease: a prospective study Download full text (pdf) of Vitamin D and bone metabolism in Graves’ disease: a prospective study
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Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
Part of Nature Communications, 2023.
Article in journal
DOI for Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy Download full text (pdf) of Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
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Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events
Part of Frontiers in Genetics, 2022.
Article in journal
DOI for Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events Download full text (pdf) of Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events
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General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimization of study protocols for small molecules and monoclonal antibodies in children
Part of British Journal of Clinical Pharmacology, p. 4985-4996, 2022.
Article, review/survey
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Risk of Revision After Arthroplasty Associated withSpecific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 TwinsTreated with Arthroplasty
Part of Journal of Bone and Joint Surgery, p. 610-620, 2022.
Article in journal
DOI for Risk of Revision After Arthroplasty Associated withSpecific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 TwinsTreated with Arthroplasty Download full text (pdf) of Risk of Revision After Arthroplasty Associated withSpecific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 TwinsTreated with Arthroplasty
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Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate
Part of Pharmacogenomics (London), p. 813-820, 2022.
Article in journal
DOI for Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate Download full text (pdf) of Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate
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The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms
Part of Clinical Pharmacology and Therapeutics, p. 1007-1021, 2022.
Article in journal
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Implementing precision medicine in a regionally organized healthcare system in Sweden.
Part of Nature Medicine, p. 1980-1982, 2022.
Article in journal
DOI for Implementing precision medicine in a regionally organized healthcare system in Sweden.
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Mast cell chymase has a negative impact on human osteoblasts
Part of Matrix Biology, p. 1-19, 2022.
Article in journal
DOI for Mast cell chymase has a negative impact on human osteoblasts Download full text (pdf) of Mast cell chymase has a negative impact on human osteoblasts
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Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes
Part of Frontiers in Genetics, 2022.
Article in journal
DOI for Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes Download full text (pdf) of Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes
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Chapter 73: Pharmacogenetics
Part of Tietz Textbook of Laboratory Medicine, 7th Edition, 2022.
Chapter in book
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The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design
Part of BMC Medicine, 2022.
Article in journal
DOI for The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design Download full text (pdf) of The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design
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Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden
Part of Respiratory Medicine, 2022.
Article in journal
DOI for Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden Download full text (pdf) of Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden
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HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease
Part of Clinical and Translational Science, p. 1249-1256, 2022.
Article in journal
DOI for HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease Download full text (pdf) of HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease
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Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes
Part of Bone Reports, 2021.
Article in journal
DOI for Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes
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Technological readiness and implementation of genomic-driven precision medicine for complex diseases
Part of Journal of Internal Medicine, p. 602-620, 2021.
Article, review/survey
DOI for Technological readiness and implementation of genomic-driven precision medicine for complex diseases Download full text (pdf) of Technological readiness and implementation of genomic-driven precision medicine for complex diseases
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Association of Variants Near the Bradykinin Receptor B2 Gene With Angioedema in Patients Taking ACE Inhibitors
Part of Journal of the American College of Cardiology, p. 696-709, 2021.
Article in journal
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Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate
Part of Pharmacogenomics (London), p. 973-982, 2021.
Article in journal
DOI for Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate Download full text (pdf) of Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate
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Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial
Part of JAMA Network Open, 2021.
Article in journal
DOI for Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial Download full text (pdf) of Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial
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Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis
Part of Journal of the American Heart Association, 2021.
Article in journal
DOI for Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis Download full text (pdf) of Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis
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Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years
Part of Journal of Clinical Endocrinology and Metabolism, p. 2840-2854, 2021.
Article in journal
DOI for Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years Download full text (pdf) of Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years
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Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index?
Part of International Journal of Epidemiology, p. 234-244, 2021.
Article in journal
DOI for Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index? Download full text (pdf) of Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index?
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Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study
Part of Diabetologia, p. 1348-1357, 2021.
Article in journal
DOI for Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study Download full text (pdf) of Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study
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Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens
Part of Clinical Pharmacology and Therapeutics, p. 1125-1135, 2021.
Article in journal
DOI for Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens Download full text (pdf) of Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens
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Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema
Part of Pharmacogenomics (London), p. 319-321, 2021.
Article in journal
DOI for Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema
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Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study
Part of European Heart Journal, p. 243-252, 2021.
Article in journal
DOI for Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study Download full text (pdf) of Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study
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[New recommendation on pharmacogenetic screening prior to 5-fluorouracil based cancer treatment - Swedish experience indicates less adverse effects and healthcare cost savings]
Part of Läkartidningen, 2021.
Article in journal
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Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations
Part of npj Primary Care Respiratory Medicine, 2021.
Article in journal
DOI for Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations Download full text (pdf) of Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations
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High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis
Part of Frontiers in Genetics, 2020.
Article in journal
DOI for High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis Download full text (pdf) of High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis
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Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations
Part of Genes, 2020.
Article in journal
DOI for Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations Download full text (pdf) of Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations
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SWEDEGENE: a Swedish nation-wide DNA sample collection for pharmacogenomic studies of serious adverse drug reactions
Part of The Pharmacogenomics Journal, p. 579-585, 2020.
Article in journal
DOI for SWEDEGENE: a Swedish nation-wide DNA sample collection for pharmacogenomic studies of serious adverse drug reactions Download full text (pdf) of SWEDEGENE: a Swedish nation-wide DNA sample collection for pharmacogenomic studies of serious adverse drug reactions
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MTHFR, TYMS and SLCO1B1 polymorphisms and adverse liver effects of methotrexate in rheumatoid arthritis
Part of Pharmacogenomics (London), p. 337-346, 2020.
Article in journal
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Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.
Part of Journal of Clinical Pharmacy and Therapeutics, p. 1021-1029, 2020.
Article in journal
DOI for Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial. Download full text (pdf) of Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.
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Comprehensive medication reviews by ward-based pharmacists in Swedish hospitals: What does the patient have to say?
Part of Journal of Evaluation In Clinical Practice, p. 149-157, 2020.
Article in journal
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Facilitators and barriers for performing comprehensive medication reviews and follow-up by multiprofessional teams in older hospitalised patients
Part of European Journal of Clinical Pharmacology, p. 775-784, 2020.
Article in journal
DOI for Facilitators and barriers for performing comprehensive medication reviews and follow-up by multiprofessional teams in older hospitalised patients Download full text (pdf) of Facilitators and barriers for performing comprehensive medication reviews and follow-up by multiprofessional teams in older hospitalised patients
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Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and angiotensin receptor blocker-induced angioedema
Part of Clinical Pharmacology and Therapeutics, p. 1195-1202, 2020.
Article in journal
DOI for Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and angiotensin receptor blocker-induced angioedema Download full text (pdf) of Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and angiotensin receptor blocker-induced angioedema
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Combined associations of body mass index and adherence to a Mediterranean-like diet with all-cause and cardiovascular mortality: A cohort study
Part of PLoS Medicine, 2020.
Article in journal
DOI for Combined associations of body mass index and adherence to a Mediterranean-like diet with all-cause and cardiovascular mortality: A cohort study Download full text (pdf) of Combined associations of body mass index and adherence to a Mediterranean-like diet with all-cause and cardiovascular mortality: A cohort study
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Next-Generation Sequencing of CYP2C19 in Stent Thrombosis: Implications for Clopidogrel Pharmacogenomics.
Part of Cardiovascular Drugs and Therapy, p. 549-559, 2020.
Article in journal
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Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment.
Part of The Pharmacogenomics Journal, p. 770-783, 2020.
Article in journal
DOI for Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment. Download full text (pdf) of Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment.
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Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders
Part of Psychoneuroendocrinology, 2020.
Article in journal
DOI for Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders Download full text (pdf) of Daytime melatonin levels in saliva are associated with inflammatory markers and anxiety disorders
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CYP2C9, VKORC1, and CYP4F2 polymorphisms and pediatric warfarin maintenance dose: a systematic review and meta-analysis
Part of The Pharmacogenomics Journal, p. 306-319, 2020.
Article, review/survey
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A sensitive method detecting trace levels of levonorgestrel using LC-HRMS.
Part of Contraception, p. 247-249, 2019.
Article in journal
DOI for A sensitive method detecting trace levels of levonorgestrel using LC-HRMS.
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A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury
Part of Gastroenterology, p. 1707-1716, 2019.
Article in journal
DOI for A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury
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Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing
Part of PLOS ONE, 2019.
Article in journal
DOI for Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing Download full text (pdf) of Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing
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Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival
Part of EBioMedicine, p. 595-604, 2019.
Article in journal
DOI for Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival Download full text (pdf) of Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival
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Disentangling the genetics of lean mass
Part of American Journal of Clinical Nutrition, p. 276-287, 2019.
Article in journal
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Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice
Part of INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, p. 1226-1232, 2019.
Article in journal
DOI for Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice Download full text (pdf) of Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long-term follow-up of predictors, surveillance, and outcome in clinical practice