Department of Medical Sciences

Department of Medical ... Research Endocrinology and Mineral ... Publications

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Publikationer från Endokrinologi och mineralmetabolism

Här visas de 50 senaste publikationerna från forskargruppen Endokrinologi och mineralmetabolism.

Pituitary function before and after surgery for nonfunctioning pituitary adenomas-data from the Swedish Pituitary Register

Al-Shamkhi, Nasrin; Berinder, Katarina; Borg, Henrik; Burman, Pia et al.

Part of European Journal of Endocrinology, p. 217-224, 2023.

Article in journal

DOI for Pituitary function before and after surgery for nonfunctioning pituitary adenomas-data from the Swedish Pituitary Register Download full text (pdf) of Pituitary function before and after surgery for nonfunctioning pituitary adenomas-data from the Swedish Pituitary Register

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Salivary cortisol and cortisone in diagnosis of Cushing's syndrome - a comparison of six different analytical methods

Bäcklund, Nils; Brattsand, Göran; Lundstedt, Staffan; Aardal, Elisabeth et al.

Part of Clinical Chemistry and Laboratory Medicine, p. 1780-1791, 2023.

Article in journal

DOI for Salivary cortisol and cortisone in diagnosis of Cushing's syndrome - a comparison of six different analytical methods
Genetics of tibia bone properties of crossbred commercial laying hens in different housing systems

Johnsson, Martin; Wall, Helena; Lopes Pinto, Fernando A.; Fleming, Robert H. et al.

Part of G3, 2023.

Article in journal

DOI for Genetics of tibia bone properties of crossbred commercial laying hens in different housing systems Download full text (pdf) of Genetics of tibia bone properties of crossbred commercial laying hens in different housing systems

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Khamisi, Selwan

Graves' Disease; Aspects on Orbitopathy and Bone Metabolism

2023.

Doctoral thesis, comprehensive summary

Download full text (pdf) of Khamisi, Selwan

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Comparison between thyroid stimulating immunoglobulin and TSH-receptor antibodies in management of Graves' orbitopathy

Khamisi, Selwan; Lundqvist, Martin; Edén Engström, Britt; Larsson, Anders et al.

Part of Experimental and clinical endocrinology & diabetes, p. 236-241, 2023.

Article in journal

DOI for Comparison between thyroid stimulating immunoglobulin and TSH-receptor antibodies in management of Graves' orbitopathy Download full text (pdf) of Comparison between thyroid stimulating immunoglobulin and TSH-receptor antibodies in management of Graves' orbitopathy

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Vitamin D and bone metabolism in Graves’ disease: a prospective study

Khamisi, Selwan; Lundqvist, Martin H.; Rasmusson, Annica J.; Edén Engström, Britt et al.

Part of Journal of Endocrinological Investigation, p. 425-433, 2023.

Article in journal

DOI for Vitamin D and bone metabolism in Graves’ disease: a prospective study Download full text (pdf) of Vitamin D and bone metabolism in Graves’ disease: a prospective study

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Exploring gender dysphoria and related outcomes in a prospective cohort study: protocol for the Swedish Gender Dysphoria Study (SKDS)

Özel, Faith; Indremo, Malin; Karamanis, Georgios; Elofsson, Ulf et al.

Part of BMJ Open, 2023.

Article in journal

DOI for Exploring gender dysphoria and related outcomes in a prospective cohort study: protocol for the Swedish Gender Dysphoria Study (SKDS) Download full text (pdf) of Exploring gender dysphoria and related outcomes in a prospective cohort study: protocol for the Swedish Gender Dysphoria Study (SKDS)

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Long-term outcomes of patients with acromegaly: a report from the Swedish Pituitary Register

Arnardottir, Steinunn; Järås, Jacob; Burman, Pia; Berinder, Katarina et al.

Part of European Journal of Endocrinology, p. 329-339, 2022.

Article in journal

DOI for Long-term outcomes of patients with acromegaly: a report from the Swedish Pituitary Register
Increased Mortality Persists after Treatment of Cushing's Disease: A Matched Nationwide Cohort Study

Bengtsson, Daniel; Ragnarsson, Oskar; Berinder, Katarina; Dahlqvist, Per et al.

Part of Journal of the Endocrine Society, 2022.

Article in journal

DOI for Increased Mortality Persists after Treatment of Cushing's Disease: A Matched Nationwide Cohort Study Download full text (pdf) of Increased Mortality Persists after Treatment of Cushing's Disease: A Matched Nationwide Cohort Study

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Real-World Effectiveness of Anti-Resorptive Treatment in Patients With Incident Fragility Fractures: The STORM Cohort – A Swedish Retrospective Observational Study

Freyschuss, Bo; Svensson, Maria K.; Cars, Thomas; Lindhagen, Lars et al.

Part of Journal of Bone and Mineral Research, p. 649-659, 2022.

Article in journal

DOI for Real-World Effectiveness of Anti-Resorptive Treatment in Patients With Incident Fragility Fractures: The STORM Cohort – A Swedish Retrospective Observational Study Download full text (pdf) of Real-World Effectiveness of Anti-Resorptive Treatment in Patients With Incident Fragility Fractures: The STORM Cohort – A Swedish Retrospective Observational Study

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Natural history and surgical outcome of Rathke's cleft cysts-A study from the Swedish Pituitary Registry

Petersson, Maria; Berinder, Katarina; Edén Engström, Britt; Tsatsaris, Erika et al.

Part of Clinical Endocrinology, p. 54-61, 2022.

Article in journal

DOI for Natural history and surgical outcome of Rathke's cleft cysts-A study from the Swedish Pituitary Registry Download full text (pdf) of Natural history and surgical outcome of Rathke's cleft cysts-A study from the Swedish Pituitary Registry

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NT-proBNP and stem cell factor plasma concentrations are independently associated with cardiovascular outcomes in end-stage renal disease hemodialysis patients

Rossignol, P; Duarte, K; Bresso, E; A, Åsberg et al.

Part of European Heart Journal Open, 2022.

Article in journal

DOI for NT-proBNP and stem cell factor plasma concentrations are independently associated with cardiovascular outcomes in end-stage renal disease hemodialysis patients Download full text (pdf) of NT-proBNP and stem cell factor plasma concentrations are independently associated with cardiovascular outcomes in end-stage renal disease hemodialysis patients

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Integument, mortality, and skeletal strength in extended production cycles for laying hens - effects of genotype and dietary zinc source

Wall, H.; Boyner, M.; de Koning, D. J.; Kindmark, Andreas et al.

Part of British Poultry Science, p. 115-124, 2022.

Article in journal

DOI for Integument, mortality, and skeletal strength in extended production cycles for laying hens - effects of genotype and dietary zinc source

Open access
Novel Biomarkers Detected by Proteomics Predict Death and Cardiovascular Events in Hemodialysis Patients

Wu, Ping-Hsun; Glerup, Rie Io; Svensson, My Hanna Sofia; Eriksson, Niclas et al.

Part of Biomedicines, 2022.

Article in journal

DOI for Novel Biomarkers Detected by Proteomics Predict Death and Cardiovascular Events in Hemodialysis Patients Download full text (pdf) of Novel Biomarkers Detected by Proteomics Predict Death and Cardiovascular Events in Hemodialysis Patients

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Psychotropic Drugs in Patients with Cushing's Disease Before Diagnosis and at Long-Term Follow-Up: A Nationwide Study

Bengtsson, Daniel; Ragnarsson, Oskar; Berinder, Katarina; Dahlqvist, Per et al.

Part of Journal of Clinical Endocrinology and Metabolism, p. 1750-1760, 2021.

Article in journal

DOI for Psychotropic Drugs in Patients with Cushing's Disease Before Diagnosis and at Long-Term Follow-Up: A Nationwide Study Download full text (pdf) of Psychotropic Drugs in Patients with Cushing's Disease Before Diagnosis and at Long-Term Follow-Up: A Nationwide Study

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Potential Transcriptional Biomarkers to Guide Glucocorticoid Replacement in Autoimmune Addison's Disease

Bjorvatn Saevik, Åse; Wolff, Anette B.; Björnsdottir, Sigridur; Simunkova, Katerina et al.

Part of Journal of the Endocrine Society, 2021.

Article in journal

DOI for Potential Transcriptional Biomarkers to Guide Glucocorticoid Replacement in Autoimmune Addison's Disease Download full text (pdf) of Potential Transcriptional Biomarkers to Guide Glucocorticoid Replacement in Autoimmune Addison's Disease

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Corticotroph aggressive pituitary tumors and carcinomas frequently harbour ATRX mutations

Casar Borota, Olivera; Boldt, Henning Bünsow; Edén Engström, Britt; Andersen, Marianne Skovsager et al.

Part of Journal of Clinical Endocrinology and Metabolism, p. 1183-1194, 2021.

Article in journal

DOI for Corticotroph aggressive pituitary tumors and carcinomas frequently harbour ATRX mutations Download full text (pdf) of Corticotroph aggressive pituitary tumors and carcinomas frequently harbour ATRX mutations

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What Cut-Point in Gait Speed Best Discriminates Community-Dwelling Older Adults With Mobility Complaints From Those Without?: A Pooled Analysis From the Sarcopenia Definitions and Outcomes Consortium

Cawthon, Peggy M.; Patel, Sheena M.; Kritchevsky, Stephen B.; Newman, Anne B. et al.

Part of The journals of gerontology. Series A, Biological sciences and medical sciences, p. E321-E327, 2021.

Article in journal

DOI for What Cut-Point in Gait Speed Best Discriminates Community-Dwelling Older Adults With Mobility Complaints From Those Without?: A Pooled Analysis From the Sarcopenia Definitions and Outcomes Consortium
Serum Glycine Levels Are Associated With Cortical Bone Properties and Fracture Risk in Men

Eriksson, Anna L.; Friedrich, Nele; Karlsson, Magnus K.; Ljunggren, Östen et al.

Part of Journal of Clinical Endocrinology and Metabolism, p. E5021-E5029, 2021.

Article in journal

DOI for Serum Glycine Levels Are Associated With Cortical Bone Properties and Fracture Risk in Men Download full text (pdf) of Serum Glycine Levels Are Associated With Cortical Bone Properties and Fracture Risk in Men

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Improved Urinary Cortisol Metabolome in Addison Disease: A Prospective Trial of Dual-Release Hydrocortisone

Espiard, Stephanie; McQueen, Johanna; Sherlock, Mark; Ragnarsson, Oskar et al.

Part of Journal of Clinical Endocrinology and Metabolism, p. 814-825, 2021.

Article in journal

DOI for Improved Urinary Cortisol Metabolome in Addison Disease: A Prospective Trial of Dual-Release Hydrocortisone Download full text (pdf) of Improved Urinary Cortisol Metabolome in Addison Disease: A Prospective Trial of Dual-Release Hydrocortisone

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Vitamin D status and current policies to achieve adequate vitamin D intake in the Nordic countries

Itkonen, Suvi T.; Andersen, Rikke; Björk, Anne K.; Brugård Konde, Åsa et al.

Part of Scandinavian Journal of Public Health, p. 616-627, 2021.

Article, review/survey

DOI for Vitamin D status and current policies to achieve adequate vitamin D intake in the Nordic countries
Prevalence of Nelson's syndrome after bilateral adrenalectomy in patients with cushing's disease: a systematic review and meta-analysis

Papakokkinou, Eleni; Piasecka, Marta; Carlsen, Hanne Krage; Chantzichristos, Dimitrios et al.

Part of Pituitary, p. 797-809, 2021.

Article, review/survey

DOI for Prevalence of Nelson's syndrome after bilateral adrenalectomy in patients with cushing's disease: a systematic review and meta-analysis Download full text (pdf) of Prevalence of Nelson's syndrome after bilateral adrenalectomy in patients with cushing's disease: a systematic review and meta-analysis

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Complications and adverse effects related to surgical and medical treatment in patients with inflammatory bowel disease in a prospectively recruited population-based cohort

Rönnblom, Anders; Ljunggren, Östen; Karlbom, Urban

Part of Scandinavian Journal of Gastroenterology, p. 1296-1303, 2021.

Article in journal

DOI for Complications and adverse effects related to surgical and medical treatment in patients with inflammatory bowel disease in a prospectively recruited population-based cohort
Treatment of patients with Graves' disease in Sweden compared to international surveys of an 'index patient'

Sjölin, Gabriel; Byström, Kristina; Holmberg, Mats; Törring, Ove et al.

Part of ENDOCRINOLOGY DIABETES & METABOLISM, 2021.

Article in journal

DOI for Treatment of patients with Graves' disease in Sweden compared to international surveys of an 'index patient' Download full text (pdf) of Treatment of patients with Graves' disease in Sweden compared to international surveys of an 'index patient'

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Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis

Tebani, Abdellah; Jotanovic, Jelena; Hekmati, Neda; Sivertsson, Åsa et al.

Part of Acta neuropathologica communications, 2021.

Article in journal

DOI for Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis

Open access
Histopathological findings in the landscape of IgG4-related pathology in patients with pituitary dysfunction: Review of six cases

Vasaitis, Lilian; Wikström, Johan; Ahlström, Sengul; Gudjonsson, Olafur et al.

Part of Journal of neuroendocrinology, 2021.

Article in journal

DOI for Histopathological findings in the landscape of IgG4-related pathology in patients with pituitary dysfunction: Review of six cases Download full text (pdf) of Histopathological findings in the landscape of IgG4-related pathology in patients with pituitary dysfunction: Review of six cases

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Wu, Ping-Hsun

Influence of bone-associated and cardiovascular biomarkers on vascular events and mortality in relation to renal dysfunction

2021.

Doctoral thesis, comprehensive summary

Download full text (pdf) of Wu, Ping-Hsun

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Osteoprotegerin predicts cardiovascular events in patients treated with haemodialysis

Wu, Ping-Hsun; Glerup, Rie Io; Svensson, My Hanna Sofia; Eriksson, Niclas et al.

Part of Nephrology, Dialysis and Transplantation, p. 1162-1170, 2021.

Article in journal

DOI for Osteoprotegerin predicts cardiovascular events in patients treated with haemodialysis
The relationship of indoxyl sulfate and p-cresyl sulfate with target cardiovascular proteins in hemodialysis patients

Wu, Ping-Hsun; Yi-Ting, Lin; Chiu, Yi-Wen; Baldanzi, Gabriel et al.

Part of Scientific Reports, 2021.

Article in journal

DOI for The relationship of indoxyl sulfate and p-cresyl sulfate with target cardiovascular proteins in hemodialysis patients Download full text (pdf) of The relationship of indoxyl sulfate and p-cresyl sulfate with target cardiovascular proteins in hemodialysis patients

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Reference intervals of salivary cortisol and cortisone and their diagnostic accuracy in Cushing's syndrome

Bäcklund, Nils; Brattsand, Göran; Israelsson, Marlen; Ragnarsson, Oskar et al.

Part of European Journal of Endocrinology, p. 569-582, 2020.

Article in journal

DOI for Reference intervals of salivary cortisol and cortisone and their diagnostic accuracy in Cushing's syndrome
Associations Between Apolipoprotein A1, High-Density Lipoprotein Cholesterol, and Urinary Cytokine Levels in Elderly Males and Females

Fellström, Bengt; Helmersson-Karlqvist, Johanna; Lind, Lars; Soveri, Inga et al.

Part of Journal of Interferon and Cytokine Research, p. 71-74, 2020.

Article in journal

DOI for Associations Between Apolipoprotein A1, High-Density Lipoprotein Cholesterol, and Urinary Cytokine Levels in Elderly Males and Females
High Plasma Erythropoietin Predicts Incident Fractures in Elderly Men with Normal Renal Function: The MrOS Sweden Cohort

Kristjansdottir, Hallgerdur Lind; Lewerin, Catharina; Lerner, Ulf H.; Herlitz, Hans et al.

Part of Journal of Bone and Mineral Research, p. 298-305, 2020.

Article in journal

DOI for High Plasma Erythropoietin Predicts Incident Fractures in Elderly Men with Normal Renal Function: The MrOS Sweden Cohort
Excess Morbidity Persists in Patients With Cushing's Disease During Long-term Remission: A Swedish Nationwide Study

Papakokkinou, Eleni; Olsson, Daniel S.; Chantzichristos, Dimitrios; Dahlqvist, Per et al.

Part of Journal of Clinical Endocrinology and Metabolism, p. 2616-2624, 2020.

Article in journal

DOI for Excess Morbidity Persists in Patients With Cushing's Disease During Long-term Remission: A Swedish Nationwide Study
Real-world effectiveness of osteoporosis treatment in the oldest old

Ström, O.; Lauppe, R.; Ljunggren, Östen; Spångéus, A. et al.

Part of Osteoporosis International, p. 1525-1533, 2020.

Article in journal

DOI for Real-world effectiveness of osteoporosis treatment in the oldest old Download full text (pdf) of Real-world effectiveness of osteoporosis treatment in the oldest old

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Associations of Bone Turnover Markers with Cognitive Function in Patients Undergoing Hemodialysis

Wu, Ping-Hsun; Lin, Yi-Ting; Chen, Cheng-Sheng; Chiu, Yi-Wen et al.

Part of Disease Markers, 2020.

Article in journal

DOI for Associations of Bone Turnover Markers with Cognitive Function in Patients Undergoing Hemodialysis Download full text (pdf) of Associations of Bone Turnover Markers with Cognitive Function in Patients Undergoing Hemodialysis

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The association between Single Nucleotide Polymorphisms of Klotho Gene and Mortality in Elderly Men: The MrOS Sweden Study

Wu, Ping-Hsun; Westerberg, Per-Anton; Kindmark, Andreas; Tivesten, Åsa et al.

Part of Scientific Reports, 2020.

Article in journal

DOI for The association between Single Nucleotide Polymorphisms of Klotho Gene and Mortality in Elderly Men: The MrOS Sweden Study Download full text (pdf) of The association between Single Nucleotide Polymorphisms of Klotho Gene and Mortality in Elderly Men: The MrOS Sweden Study

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Association between Circulation Indole-3-Acetic Acid Levels and Stem Cell Factor in Maintenance Hemodialysis Patients: A Cross-Sectional Study

Wu, Ping-Hsun; Yi-Ting, Lin; Wu, Pei-Yu; Lee, Hei-Hwa et al.

Part of Journal of Clinical Medicine, 2020.

Article in journal

DOI for Association between Circulation Indole-3-Acetic Acid Levels and Stem Cell Factor in Maintenance Hemodialysis Patients: A Cross-Sectional Study Download full text (pdf) of Association between Circulation Indole-3-Acetic Acid Levels and Stem Cell Factor in Maintenance Hemodialysis Patients: A Cross-Sectional Study

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Risk of imminent fracture following a previous fracture in a Swedish database study

Banefelt, J.; Akesson, K. E.; Spangeus, A.; Ljunggren, Östen et al.

Part of Osteoporosis International, p. 601-609, 2019.

Article in journal

DOI for Risk of imminent fracture following a previous fracture in a Swedish database study Download full text (pdf) of Risk of imminent fracture following a previous fracture in a Swedish database study

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Variations in the vitamin D receptor gene are not associated with measures of muscle strength, physical performance, or falls in elderly men: Data from MrOS Sweden

Björk, Anne; Ribom, Eva; Johansson, Gunnar; Scragg, R. et al.

Part of Journal of Steroid Biochemistry and Molecular Biology, p. 160-165, 2019.

Article in journal

DOI for Variations in the vitamin D receptor gene are not associated with measures of muscle strength, physical performance, or falls in elderly men: Data from MrOS Sweden
Expanding the phenotypic spectrum of osteogenesis imperfecta type V including heterotopic ossification of muscle origins and attachments

Clewemar, Pantelis; Hailer, Nils P.; Hailer, Yasmin; Klar, Joakim et al.

Part of Molecular Genetics & Genomic Medicine, 2019.

Article in journal

DOI for Expanding the phenotypic spectrum of osteogenesis imperfecta type V including heterotopic ossification of muscle origins and attachments Download full text (pdf) of Expanding the phenotypic spectrum of osteogenesis imperfecta type V including heterotopic ossification of muscle origins and attachments

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Gaucher Disease in Bone: From Pathophysiology To Practice

Hughes, Derralynn; Mikosch, Peter; Belmatoug, Nadia; Carubbi, Francesca et al.

Part of Journal of Bone and Mineral Research, p. 996-1013, 2019.

Article, review/survey

DOI for Gaucher Disease in Bone: From Pathophysiology To Practice Download full text (pdf) of Gaucher Disease in Bone: From Pathophysiology To Practice

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Disentangling the genetics of lean mass

Karasik, David; Zillikens, M. Carola; Hsu, Yi-Hsiang; Aghdassi, Ali et al.

Part of American Journal of Clinical Nutrition, p. 276-287, 2019.

Article in journal

DOI for Disentangling the genetics of lean mass
Differing impact of clinical factors on the risk of fracture in younger and older women in the general population and an osteoporosis clinic population

Lauppe, Rosa; Åkesson, Kristina E.; Ljunggren, Östen; Spangeus, Anna et al.

Part of Archives of Osteoporosis, 2019.

Article in journal

DOI for Differing impact of clinical factors on the risk of fracture in younger and older women in the general population and an osteoporosis clinic population
The incidence of Cushing's disease: a nationwide Swedish study

Ragnarsson, Oskar; Olsson, Daniel S.; Chantzichristos, Dimitrios; Papakokkinou, Eleni et al.

Part of Pituitary, p. 179-186, 2019.

Article in journal

DOI for The incidence of Cushing's disease: a nationwide Swedish study Download full text (pdf) of The incidence of Cushing's disease: a nationwide Swedish study

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Overall and Disease-Specific Mortality in Patients With Cushing Disease: A Swedish Nationwide Study

Ragnarsson, Oskar; Olsson, Daniel S.; Papakokkinou, Eleni; Chantzichristos, Dimitrios et al.

Part of Journal of Clinical Endocrinology and Metabolism, p. 2375-2384, 2019.

Article in journal

DOI for Overall and Disease-Specific Mortality in Patients With Cushing Disease: A Swedish Nationwide Study
Pituitary Metastases: A Nationwide Study on Current Characteristics With Special Reference to Breast Cancer

Schill, Fredrika; Nilsson, Margareta; Olsson, Daniel S.; Ragnarsson, Oskar et al.

Part of Journal of Clinical Endocrinology and Metabolism, p. 3379-3388, 2019.

Article in journal

DOI for Pituitary Metastases: A Nationwide Study on Current Characteristics With Special Reference to Breast Cancer
The Long-Term Outcome of Treatment for Graves' Hyperthyroidism

Sjölin, Gabriel; Holmberg, Mats; Törring, Ove; Byström, Kristina et al.

Part of Thyroid, p. 1545-1557, 2019.

Article in journal

DOI for The Long-Term Outcome of Treatment for Graves' Hyperthyroidism
Impaired Quality of Life After Radioiodine Therapy Compared to Antithyroid Drugs or Surgical Treatment for Graves' Hyperthyroidism: A Long-Term Follow-Up with the Thyroid-Related Patient-Reported Outcome Questionnaire and 36-Item Short Form Health Status Survey

Törring, Ove; Watt, Torquil; Sjölin, Gabriel; Byström, Kristina et al.

Part of Thyroid, p. 322-331, 2019.

Article in journal

DOI for Impaired Quality of Life After Radioiodine Therapy Compared to Antithyroid Drugs or Surgical Treatment for Graves' Hyperthyroidism: A Long-Term Follow-Up with the Thyroid-Related Patient-Reported Outcome Questionnaire and 36-Item Short Form Health Status Survey
Exploring the Benefit of 2-Methylbutyric Acid in Patients Undergoing Hemodialysis Using a Cardiovascular Proteomics Approach

Wu, Ping-Hsun; Chiu, Yi-Wen; Zou, Hsin-Bai; Hsu, Cheng-Chih et al.

Part of Nutrients, 2019.

Article in journal

DOI for Exploring the Benefit of 2-Methylbutyric Acid in Patients Undergoing Hemodialysis Using a Cardiovascular Proteomics Approach Download full text (pdf) of Exploring the Benefit of 2-Methylbutyric Acid in Patients Undergoing Hemodialysis Using a Cardiovascular Proteomics Approach

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A Low Ankle-Brachial Index and High Brachial-Ankle Pulse Wave Velocity Are Associated with Poor Cognitive Function in Patients Undergoing Hemodialysis

Wu, Ping-Hsun; Yi-Ting, Lin; Wu, Pei-Yu; Huang, Jiun-Chi et al.

Part of Disease Markers, 2019.

Article in journal

DOI for A Low Ankle-Brachial Index and High Brachial-Ankle Pulse Wave Velocity Are Associated with Poor Cognitive Function in Patients Undergoing Hemodialysis Download full text (pdf) of A Low Ankle-Brachial Index and High Brachial-Ankle Pulse Wave Velocity Are Associated with Poor Cognitive Function in Patients Undergoing Hemodialysis

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Last modified: 2022-06-09