Molecular Medicine research group

• Raine A, Manlig E, Wahlberg P, Syvänen AC, Nordlund J (2017) SPlinted Ligation Adapter Tagging (SPLAT), a novel library preparation method for whole genome bisulphite sequencing. Nucleic Acid Res 45(6), e36 
• Lindqvist CM, Lundmark A, Nordlund J, Freyhult E, Ekman D, Carlsson Almlöf J, Raine A, Övernäs E, Abrahamsson J, Frost B-M, Grandér D, Heyman M, Palle J, Forestier E, Lönnerholm G, Berglund EC, Syvänen A-C (2016) Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes. Oncotarget 7(39), 64071-64088
• Bentham J, Morris DL, Cunninghame Graham DS, Pinder CL, Tombleson P, Behrens TW, Martin J, Fairfax BP, Knight JC, Chen L, Replogle J, Syvanen A-C, Ronnblom L, Graham RR, Wither JE, Rioux JD, Alarcon-Riquelme ME, Vyse TJ (2015) Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nat Genet 47(12), 1457-1464
• Nordlund J, Bäcklin C, Wahlberg P, Busche S, Berglund E, Eloranta M-L, ... , Sinnett D, Söderhäll S, Pastinen T, Gustafsson M, Lönnerholm G, Syvänen A-C (2013) Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia. Genome Biol 14(9), r105
• Lappalainen T, Sammeth M, Friedlander MR, t Hoen PAC, Monlong J, Rivas MA, ... , Meitinger T, Rosenstiel P, Guigo R, Gut IG, Estivill X, Dermitzakis ET (2013) Transcriptome and genome sequencing uncovers functional variation in humans. Nature, 501(7468), 506-511
• Wang C, Sandling JK, Hagberg N, Berggren O, Sigurdsson S, Karlberg O, Rönnblom L, Eloranta ML, Syvänen AC (2013) Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4. Ann Rheum Dis, 72(1), 96-103.
• Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, ... , Seldin MF, Rönnblom L, Criswell LA, Syvänen AC, Behrens TW, & Graham RR (2009) A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet, 41(11), 1228-1233
• Milani L, Lundmark A, Nordlund J, Kiialainen A, Flaegstad T, Jonmundsson G, Kanerva J, Schmiegelow K, Gunderson KL, Lönnerholm G, & Syvänen AC (2009) Allele-specific gene expression patterns in primary leukemic cells reveal regulation of gene expression by CpG site methylation. Genome Res, 19(1), 1-11
• Hom G, Graham R, Modrek B, Taylor K, Ortmann W, Garnier S, ... , Seldin M, Rönnblom L, Syvänen A-C, Criswell L, Gregersen P, Behrens T (2008) Association of Systemic Lupus Erythematosus with C8orf13–BLK and ITGAM–ITGAX.N Engl J Med, 358(9):900-909 
• Sigurdsson S, Nordmark G, Goring HH, Lindroos K, Wiman AC, Sturfelt G, Jonsen A, Rantapaa-Dahlqvist S, Moller B, Kere J, Koskenmies S, Widen E, Eloranta ML, Julkunen H, Kristjansdottir H, Steinsson K, Alm G, Ronnblom L, Syvänen A-C (2005) Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet, 76:528-537

Review articles

• Nordlund J, Syvänen AC (2017) Epigenetics in pediatric acute lymphoblastic leukemia. Semin Cancer Biol, 17:30091-30093
• Syvänen (2005) Toward genome-wide SNP genotyping. Nat Genet, 37 S5-10
• Syvänen (2001) Accessing genetic variation: Genotyping single nucleotide polymorphisms. Nat Rev Genet, 2:930-942