Molecular Medicine research group
Favorite publications from the Molecular Medicine group:
- Marincevic-Zuniga Y, Dahlberg J, Nilsson S, Raine A, Nystedt SW, Lindqvist CM, Berglund EC, Abrahamsson J, Cavelier L, Forestier E, Heyman M, Lönnerholm G, Nordlund J, Syvänen A-C. Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profiles. Journal of Hematology & Oncology, in press, 2017.
- Raine A, Manlig E, Wahlberg P, Syvänen AC, Nordlund J (2017) SPlinted Ligation Adapter Tagging (SPLAT), a novel library preparation method for whole genome bisulphite sequencing. Nucleic Acid Res 45(6), e36
- Bentham J, Morris DL, Cunninghame Graham DS, Pinder CL, Tombleson P, Behrens TW, Martin J, Fairfax BP, Knight JC, Chen L, Replogle J, Syvanen A-C, Ronnblom L, Graham RR, Wither JE, Rioux JD, Alarcon-Riquelme ME, Vyse TJ (2015) Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nat Genet 47(12), 1457-1464
- Nordlund J, Bäcklin C, Wahlberg P, Busche S, Berglund E, Eloranta M-L, ... , Sinnett D, Söderhäll S, Pastinen T, Gustafsson M, Lönnerholm G, Syvänen A-C (2013) Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia. Genome Biol 14(9), r105
- Lappalainen T, Sammeth M, Friedlander MR, t Hoen PAC, Monlong J, Rivas MA, ... , Meitinger T, Rosenstiel P, Guigo R, Gut IG, Estivill X, Dermitzakis ET (2013) Transcriptome and genome sequencing uncovers functional variation in humans. Nature, 501(7468), 506-511
- Wang C, Sandling JK, Hagberg N, Berggren O, Sigurdsson S, Karlberg O, Rönnblom L, Eloranta ML, Syvänen AC (2013) Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4. Ann Rheum Dis, 72(1), 96-103.
- Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, ... , Seldin MF, Rönnblom L, Criswell LA, Syvänen AC, Behrens TW, & Graham RR (2009) A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet, 41(11), 1228-1233
- Milani L, Lundmark A, Nordlund J, Kiialainen A, Flaegstad T, Jonmundsson G, Kanerva J, Schmiegelow K, Gunderson KL, Lönnerholm G, & Syvänen AC (2009) Allele-specific gene expression patterns in primary leukemic cells reveal regulation of gene expression by CpG site methylation. Genome Res, 19(1), 1-11
- Hom G, Graham R, Modrek B, Taylor K, Ortmann W, Garnier S, ... , Seldin M, Rönnblom L, Syvänen A-C, Criswell L, Gregersen P, Behrens T (2008) Association of Systemic Lupus Erythematosus with C8orf13–BLK and ITGAM–ITGAX.N Engl J Med, 358(9):900-909
- Sigurdsson S, Nordmark G, Goring HH, Lindroos K, Wiman AC, Sturfelt G, Jonsen A, Rantapaa-Dahlqvist S, Moller B, Kere J, Koskenmies S, Widen E, Eloranta ML, Julkunen H, Kristjansdottir H, Steinsson K, Alm G, Ronnblom L, Syvänen A-C (2005) Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am J Hum Genet, 76:528-537
Review articles
- Nordlund J, Syvänen AC (2017) Epigenetics in pediatric acute lymphoblastic leukemia. Semin Cancer Biol, 17:30091-30093
- Syvänen (2005) Toward genome-wide SNP genotyping. Nat Genet, 37 S5-10
- Syvänen (2001) Accessing genetic variation: Genotyping single nucleotide polymorphisms. Nat Rev Genet, 2:930-942
Recent publications
- The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome. 2020
- Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing. 2021
- Recent advances in single-molecule fluorescence microscopy render structural biology dynamic. 2020
- Plasma proteomics and lung function in four community-based cohorts.. 2020
- Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and angiotensin receptor blocker-induced angioedema. 2020
- Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling. 2020
- Computational and Statistical Analysis of Array-Based DNA Methylation Data. 2019
- Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL. 2020
- Type 2 diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Elderly Swedish Men and Women.
- Refined detection and phasing of structural aberrations in pediatric acute lymphoblastic leukemia by linked-read whole-genome sequencing. 2020
News
- VR-grant (3.6M SEK) 2017-11-01
- KAW-SLE Symposium 2017-02-02 2017-01-24
- The molecular medicine group is looking for a project leader with competence in bioinformatics 2016-12-15
- Launch of new homepage(s) 2016-12-07
- Novel library preparation for whole genome DNA methylation sequencing published in NAR 2016-11-30

In the spotlight
SPLAT - a new method for WGBS
Read the paper i Nucleic Acids Research